Selective Targeting of M3 Muscarinic Receptors: an Opportunity for Improved Treatment of Upper Gastrointestinal Carcinomas
نویسندگان
چکیده
PI3K: Phosphoinositide 3-Kinase; Akt or PKB: Protein Kinase B; cAMP: Cyclic Adenosine Monophosphate; ATP: Adenosine Triphosphate; NFκB: Nuclear Factor Kappa B; APC: Adenomatous Polyposis Coli; GEO: Gene Expression Omnibus; GI: Gastrointestinal; EGFR: Epidermal Growth Factor Receptor; HER2: Human Epidermal Growth Factor Receptor 2; AURKA: Aurora kinase A; IP3: Inositol Triphosphate; PLC: Phospholipase C; DAG: Diacylglycerol; MAPK: Mitogen Activated Protein Kinase; RTKs: Receptor Tyrosine Kinase; MMP9: Matrix Metalloproteinase 9; CHO: Chinese Hamster Ovary; PGE2: Prostaglandin E2; NFκB: Nuclear Factor Kappa B; COX-2: Cyclooxygenase-2; 5-FU: 5 Fluorouracil; DMSO: Dimethyl Sulfoxide
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Does Achillea millefolium extracts possess prokinetic effects on the bovine abomasum thourgh M3 muscarinic receptors?
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